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Upon the challenge of oxLDL, ATF6 dissociates from the ER membrane, moves into the Golgi apparatus, where it is cleaved into its active form (p50-ATF6), which subsequently translocates into the nucleus to regulate target genes, such as GRP78 and XBP-1 (156)

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In a hydrogen peroxide-induced oxidative stress model using porcine IECs, extracellular polysaccharides from LGG accelerated ROS clearance by upregulating antioxidant enzyme expression and downregulating oxidative stress-related proteins

When installed some trial and error adjustment of the float valve may be required to balance the makeup water with tower operation